SGX-523

Product Name: SGX-523
CAS No.: 1022150-57-7
Chemical Name: SGX-523
Synonyms: X-523;CS-331;SGX-523;α-Neurokinin;SGX-523, >=98%;SGX 523(SGX-523);SGX-523 USP/EP/BP;SGX-523;SGX523; SGX 523;6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline;6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline
CBNumber: CB42501000
Molecular Formula: C18H13N7S
Formula Weight: 359.41
MOL File: 1022150-57-7.mol

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SGX-523 Property

Density: 1.485
storage temp.: Store at -20°C
solubility: ≥17.95 mg/mL in DMSO
form: solid
pka: 3.94±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 448106
Product name: Met Kinase Inhibitor VI, SGX523 - CAS 1022150-57-7 - Calbiochem
Packaging: 5MG
Price: $201
Updated: 2024/03/01

Cayman Chemical

Product number: 18093
Product name: SGX523
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18093
Product name: SGX523
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 18093
Product name: SGX523
Purity: ≥98%
Packaging: 10mg
Price: $278
Updated: 2024/03/01

Cayman Chemical

Product number: 18093
Product name: SGX523
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

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SGX-523 Chemical Properties,Usage,Production

Uses

SGX523 is a novel, ATP-competitive kinase inhibitor.

Definition

ChEBI: A member of the class of triazolopyridazines that is 6-(1-methylpyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine-3-thiol in which the thiol hydrogen is replaced by a quinolin-6-yl group.

Biological Activity

sgx-523 is a novel, potent, atp-competitive, and highly-selective hepatocyte growth factor receptor (met) inhibitor with ic50 value of 4 nm [1].sgx523 inhibits met autophosphorylation in gastric cancer cell line gtl16 and human lung carcinoma cell line a549, with ic50 of 40 nm and 12 nm, respectively [1]. additionally, tumor regression was observed in gastic cancer cell line gtl16 and human gbm cell line u87mg derived mouse xenograft models that are treated with sgx-523 by oral gavage [1].sgx523 has been shown to inhibit the phosphorylateion of mek, mapk, akt in brain cancer cell lines including u87, u373, daoy, as well as glioma stem cells 1228. the inhibition of mek in brain cancer cells and stem cells led to cell proliferation, g1/s cell cycle progression, cell migration, and cell invasion [2].

storage

Store at +4°C

References

[1] buchanan sg1, hendle j, lee ps, smith cr, bounaud py, jessen ka, tang cm, huser nh, felce jd, froning kj, peterman mc, aubol be, gessert sf,sauder jm, schwinn kd, russell m, rooney ia, adams j, leon bc, do th, blaney jm, sprengeler pa, thompson da, smyth l, pelletier la, atwell s, holme k,wasserman sr, emtage s, burley sk, reich sh. sgx523 is an exquisitely selective, atp-competitive inhibitor of the met receptor tyrosine kinase with antitumor activity in vivo. mol cancer ther. 2009 dec;8(12):3181-90.
[2] guessous f1, zhang y, dipierro c, marcinkiewicz l, sarkaria j, schiff d, buchanan s, abounader r.an orally bioavailable c-met kinase inhibitor potently inhibits brain tumor malignancy and growth. anticancer agents med chem. 2010 jan;10(1):28-35.

SGX-523 Preparation Products And Raw materials

Raw materials

Preparation Products

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SGX-523 Suppliers

China 110 India 1 United Kingdom 2 United States 19 Global 132

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

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View Lastest Price from SGX-523 manufacturers

Career Henan Chemical Co

Product: SGX-523 1022150-57-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kgs
Release date: 2019-12-17

1022150-57-7, SGX-523Related Search:

SGX523 Capmatinib TG100-115 Selumetinib Vismodegib (GDC-0449) RO4929097 JNJ-38877605

SGX-523

6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline

SGX 523(SGX-523)

Quinoline,6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-

6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline SGX 523

SGX-523, >=98%

6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline

SGX-523;SGX523; SGX 523

CS-331

X-523

SGX-523 USP/EP/BP

α-Neurokinin

1022150-57-7

1022190-57-7

C18H13N7S

Inhibitors

API